Welcome to the Molecular Biophysics and Structural Biology Lab!
Cellular processes are mediated by the complex network of interactions between macromolecules, such as proteins and nucleic acids, and small molecules. A comprehensive understanding of this network is essential for gaining deeper insights into the mechanisms governing cellular function and how they become disrupted in various diseases. In our laboratory, we use a combination of experimental (including native mass spectrometry, cryo-EM and mass photometry) and computational approaches, interfacing structural biology and artificial intelligence, to study the complex network of interactions within model bacterial and plant systems.
Our research focuses on membrane proteins, with a particular emphasis on exploring the multi-protein complexes that facilitate the transport of lipids and proteins across the double envelope membranes found in pathogenic Gram-negative bacteria and endosymbiotic organelles like chloroplasts. Our ultimate goal is to unveil the structural dynamics of these machineries in their native environment.
Our laboratory is currently supported by funds from the Royal Society, ERC/UKRI Frontier Guarantee Programme, Diamond Light Source and the Kavli Institute for Nanoscience Discovery. If you’re interested in joining our team, please get in touch to discuss the possible project directions. Perspective students are welcome to attend our group meetings to learn more about our work and to discuss with the team informally.