Dr Max Fitz-James has been awarded a Wellcome Career Development Fellowship, a scheme which provides funding for mid-career researchers who have the potential to be international research leaders. Max has joined Biology from Oxford’s Department of Biochemistry.
Transgenerational Epigenetic Inheritance (TEI) is how non-genetic information, such as DNA methylation, histone modifications, and non-coding RNAs, are transmitted through reproductive cells and across generations. It can contribute to important observable traits including health, longevity, fertility, and adaptation to environmental challenges, including pollutants and pesticides. Max’s research will investigate the molecular mechanisms behind TEI.
Firstly, he will use the fruit fly Drosophila melanogaster to uncover how heritable epigenetic variation is established and inherited. The research focuses will be to detect the appearance of new “epimutations”, identify the molecular events that lead to their establishment, and track them through reproductive cell formation and development to determine how they are inherited.
Secondly, he will investigate the inheritance of an epigenetic trait of major importance: the swarming behaviour of the desert locust Schistocerca gregaria. This behaviour is triggered by environmental conditions, meaning that any locust has the potential to develop swarming tendencies regardless of its genes. The research will aim to identify the epigenetic signals that underpin this behaviour and determine how they are transmitted from parent to offspring.
Max said:
"I am very excited to begin my independent research career at such an outstanding institution, and to be joining at such a transformative time for the department. I look forward to setting up in the new Life and Mind Building and to the connections and collaborations this opportunity will bring."
