I investigate the mechanisms of antibiotic resistance in clinically important bacterial pathogens, with a particular focus on tigecycline resistance. My work integrates genomic and transcriptomic approaches to understand how resistance genes are maintained and disseminated within bacterial populations, examining plasmid stability, mobility potential, and their contribution to bacterial virulence and fitness.
Using whole-genome sequencing (Illumina and Nanopore) and RNA sequencing, I explore the evolutionary and regulatory basis of plasmid-mediated resistance. Complementing these molecular studies, I employ transmission and scanning electron microscopy to visualise the ultrastructural effects of tigecycline treatment on bacterial cells, providing insights into drug action and resistance-related morphological adaptations.
My broader research interests include the interaction between antibiotic resistance evolution and bacterial pathogenicity, with the goal of informing strategies to mitigate the clinical impact of multidrug-resistant infections.
I have presented my findings at major international conferences, including the largest international congress in the fields of clinical microbiology and infectious diseases, the ESCMID Global Congress in 2024 and 2025.
I am a Commonwealth Scholar and have actively contributed to research collaborations across multiple disciplines and departments. I also served as a demonstrator and contributed to teaching and outreach activities within the University of Oxford including the Department of Biology, the Sir William Dunn School of Pathology, Department of Chemistry and the Natural History Museum.
